Recent studies demonstrated that caspase-9 could be activated by the Tom20/Bax/Cytochrome c pathway in melanoma or by lobaplatin/ROS and JNK phosphorylation/Bax/Cytochrome c pathways in colon cancer, showing a great potential value of clinical application (Zhou et al., 2018; Yu et al., 2019). Here, CYCS is linked to melanoma.