Transactivation response element RNA-binding protein TARBP2 inhibits the catalytic activity of interferon-induced double-stranded RNA (dsRNA)-activated protein kinase (PKR) to regulate stress-induced signaling pathways during viral infections and cell stress, and TARBP2 is also a regulator of microRNA biogenesis and cellular stress response (Ukhueduan et al., 2021). This evidence concerns the gene EIF2AK2 and viral infectious disease.