Regarding the sagging phenotype, the “amino sugar and nucleotide sugar metabolism” pathway yielded the best FDR and the three most associated genes were PMM2, GFPT2, and GMDS. PMM2 is involved in a metabolism disorder linked with abnormal fat distribution and skin wrinkling (Kouwenberg et al., 2014). The gene discussed is GFPT2; the disease is Other metabolic disease.