These findings are in agreement with previous studies showing that Mxi1-0 activates MEK/ERK signaling and improved the proliferation of human umbilical vein endothelial cells (HUVECs), and that Mxi1-0 underlies hypoxia-induced vascular endothelial growth factor production by hepatic carcinoma cells (Hu et al., 2017; Wu et al., 2017). This evidence concerns the gene MAP2K7 and hepatocellular carcinoma.