ACTB and Thrombocytopenia: Specifically, several variants in exons 5 and 6 of ACTB were associated with syndromic thrombocytopenia (Latham et al., 2018).The c.478A > G (p.Thr160Ala) variant in this study was a heterozygous missense variant located in exon 4, and the patient showed a typical BWCFF phenotype, several routine blood tests did not indicate platelet count reduction.