CRP and Sepsis: Despite great improvement in surgery, pharmacological approaches and serum biomarkers including procalcitonin (PCT), C-reactive protein (CRP), lactate and cell-free DNA has been made in initial detection and therapy of sepsis, the incidence and mortality rates are still rising rapidly due to complexity of sepsis and lack of targeted drugs (Povoa et al., 2005; Saukkonen et al., 2008; Riedel et al., 2011; Rhee et al., 2015).