CMPK2 and acute respiratory distress syndrome: Confirmation of the association between CMPK2 and the NLRP3 inflammasome was consistent with previous studies that showed that CMPK2 was closely associated with NLRP3 inflammasome activation in hepatic ischemia/reperfusion (I/R) injury and acute respiratory distress syndrome (ARDS), which may inhibit the synthesis of ATP and mtDNA (30, 41).