Down-regulation of miR-126 (35), miR-23 (50) and up-regulation of miR-143 (43) can increase the release of inflammatory factors such as TNF-α, IL-1β, IL-6 through up-regulation of IL-23R, CXCL12 and down-regulation of IGFBP5 and thus affect the course of RA. The gene discussed is IL1B; the disease is rheumatoid arthritis.