CD4 and rheumatoid arthritis: Besides, miR-146a, miR-26, miR-let-7a, miR-146b, miR-150, miR-155 are increased and miR-363, miR-498 are decreased in the CD4+ T cell sub-type in PBMCs, Among these miRNAs, miR-146a may affect the apoptosis of T cell and RA progression by targeting IL-17 and Fas associated factor 1 (FAF1) (34, 70).