In addition, cell-derived small extracellular vesicles of miR-574-5p induces osteoclast differentiation by targeting TLR 7/8 (87), whereas miR-150-5p exosomes alleviates RA-FLS proliferation and angiogenesis and reduces RA joint destruction by targeting MMP14 and VEGF (88). This evidence concerns the gene MMP14 and rheumatoid arthritis.