PDIA3 and central nervous system cancer: Several studies indicate that PDIA3 is closely related to the progression and prognosis of gliomas (21, 23), so we further performed Kaplan–Meier curve analysis of GBM and LGG, which suggested that a higher PDIA3 expression was associated with poor survival outcomes (Figures 3C, D), indicating that PDIA3 is a prognostic biomarker of OS outcomes in LGG and GBM.