The results indicated that PDIA3 was positively associated with the infiltration levels of CD4+ T cells, CAF, progenitors of lymphoid, MDSC, neutrophils, and macrophages in most of the TCGA cancers and negatively associated with the infiltration levels of NK T cells in most TCGA cancers especially in THCA, UCS, and UVM. The gene discussed is PDIA3; the disease is cancer.