The results of OS analysis suggested that PDIA3 is a perilous factor for patients with ACC, BLCA, CESC, GBM, HNSC, KICH, KIRC, KIRP, LGG, LUAD, LUSC, MESO, PAAD, and UVM while a protective factor for patients with DLBC and OV. Here, PDIA3 is linked to glioblastoma.