Median values of CSF IL-6 (Figure S3B) and IL-10 (Figure S3C) were similar between MS (3.1 (IQR 1.6) and 0.58 (IQR 0.8) pg/ml, respectively), RIS (2.5 (IQR 1.7) and 0.58 (IQR 0.2) pg/ml, respectively), and CIS patients (2.9 (IQR 2.1) and 0.58 (IQR 0.1) pg/ml, respectively), p > 0.1 for all comparisons. The gene discussed is IL10; the disease is in situ carcinoma.