We identified a 6-protein signature (bFGF, GCSF, IFNγ, IL9, IP10, and MIP1α) that distinguished Active TB from Mtb infected, and a 4-protein signature (Eotaxin, IL1RA, IL8, and IP10) that distinguished Active TB from QFT consistent negatives with AUCs of 0.89 and 0.88, respectively. Here, FGF2 is linked to tuberculosis.