A 4-protein signature was identified, comprising bFGF, IFNγ, IL9, and IP10 (Table 3A) that differentiated Active TB from Household contacts with Mtb infection with an AUC of 0.89 (95% CI, 0.80–0.96; Figure 5A), sensitivity of 72.4% (95% CI, 52.8–87.3) and specificity of 92.6% (95% CI, 82.1–97.9) (Table 3B). This evidence concerns the gene IFNG and tuberculosis.