Higher levels of IL-1α and M-CSF were determined in both LI09 and LI10 cohorts than in PC cohort, and IL-2 and IL-17A were greater in the LI10 cohort than in the PC cohort (Supplementary Figure S1), suggesting IL-1α, M-CSF, IL-2, and IL-17A were enhanced by LI09 and/or LI10. The gene discussed is IL2; the disease is pachyonychia congenita.