IL6 and COVID-19: Moreover, CBD can downregulate the expression of COX-2, TNF-α, IL-6, CCL2, and other cytokines in a WI-38 lung fibroblast cell line model with SARS-CoV-2 infection (28), as observed in a lung epithelial cell model with the decrease in IL-6 and IL-8 secretion (29) and in intranasal of Poly I:C-induced acute respiratory viral infection of COVID-19 (30) (Table 1).