PIGF and COVID-19: A prospective multicenter study showed VEGF-A to be one of the best predictors of COVID-19 disease severity (130), and another study attempting to associate VEGF family members with in-hospital mortality due to COVID-19 reported that VEGF-A, PIGF, and FGF-2 significantly increased with disease severity (p < 0.001) with a serum PIGF cut-off of above 30pg/mL the best predictor of in-hospital mortality on survival analysis (p = 0.001).