VWF and COVID-19: In addition, A Disintegrin And Metalloproteinase with ThromboSpondin motifs 13 (ADAMTS13), which cleaves large multimeric vWF polymers into monomers to prevent thrombosis, is reportedly depleted in mechanically ventilated COVID-19 patients, and an eightfold higher vWF-to-ADAMTS13 ratio occurs in ICU-admitted and mechanically-ventilated COVID-19 patients (137, 138).