Schrezenmeier and colleagues reported that 67% of naïve HD patients displayed significantly lower levels of IFN-ɣ release than healthy controls (93%) (24), while similar findings were observed using flow cytometry by Broseta and colleagues, in which activated CD4+ T cells expressing intracellular IFN-ɣ were observed only in 62% of naïve HD patients (28). The gene discussed is CD4; the disease is Huntington disease.