In contrast to SCL and LMO1, decreased Heb gene dosage did not affect Notch1tg-induced T-ALL in Cd3e-/- or in Cd3e+/+ mice (Figures 5C–F), indicating that Heb and Notch1 operate in the same genetic pathway in T-ALL, as suggested during normal differentiation (36). This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.