FHL1 and Emery-Dreifuss muscular dystrophy: It was also demonstrated that FHL1-deficient mice were less susceptible to CHIKV infection, and more importantly, virus replication was greatly impaired in fibroblasts and myoblasts derived from Emery-Dreifuss muscular dystrophy (EDMD) patients, in which the FHL1 gene was mutated (Gueneau et al., 2009; Shathasivam et al., 2010).