CD4 and infection: HIV-1 Envs unable to stabilize microtubules (i.e., increasing post-transductional acetylation of Lys40 residue in α-tubulin), to reorganize F-actin for the delineation of pseudopod-entry virus hot zones present low CD4 binding, restricted fusion, and low early infection (Valenzuela-Fernandez et al., 2005; Barrero-Villar et al., 2009; Garcia-Exposito et al., 2013; Casado et al., 2018; Cabrera-Rodriguez et al., 2019).