Yan’s team also proved that the combination of PKA inhibitor and VCP inhibitor and M1 virus reduced the production of virus-induced PD-L1 + DC, MDSC, TAM and T-reg, thereby reduced tumor burden and improved the survival rate of mice, and eventually enhanced the oncolytic effect of M1 virus (Lin et al., 2014; Li et al., 2016; Zhang et al., 2017). The gene discussed is CD274; the disease is neoplasm.