Regarding AQP4-IgG-NMOSD, AQP4-IgG serum titer at the time of attack has been found to be higher in patients presenting with ON (38) and to be associated with the severity and outcome of the event (blindness, length of myelitis on MRI) (39, 40), however these findings were not consistently replicated in other studies (41, 42) and therefore the utility of AQP4-IgG titers in predicting disease is unclear. This evidence concerns the gene AQP4 and blindness (disorder).