Amounting evidence arising from innovative genetic testing, and particularly next-generation sequencing (NGS) techniques, has revealed that different pathogenic variants of the same gene are responsible for several epileptic phenotypes; in particular, KCNQ2-related neonatal epileptic encephalopathy (NEE) contributed to expanding the spectrum of KCNQ2-related epilepsies (5). This evidence concerns the gene KCNQ2 and epilepsy.