The demographic data and clinical variables of the two groups were compared, the results showed that compared with the control group, the GAD-7 score (Z = −6.499, P < 0.001), PHQ-9 score (Z = −7.621, P < 0.001), PSQI score was found to be increased in the morphine dependence group, the MOCA score (Z = −7.557, P < 0.001) was found to be decreased in the morphine dependence group; the level of miRNA-124 (Z = −3.017, P < 0.001) was higher than the control group, and the level of IQGAP1 (Z = −3.999, P < 0.001) was lower than the control group. Here, IQGAP1 is linked to morphine dependence.