The results of correlation analysis between OASI scores and MOCA scores in patients with morphine dependence found that the miR-124 levels (r = −0.384, P < 0.001), the IQGAP1 levels (r = −0.597, P < 0.001), GAD-7 scores (r = 0.377, P = 0.016), the average intake in the past year (r = 0.508, p = 0.001) were related to OASI scores, but GAD-7 scores were not corrected by Bonferroni (Bonferroni corrected P < 0.05/11 = 0.0045). Here, IQGAP1 is linked to morphine dependence.