In addition, other cellular physiological processes, such as extracellular vesicle release (Beghein et al., 2018), focal adhesion dynamics (Villari et al., 2015), cancer cell stemness (Barnawi et al., 2016; Kang et al., 2018; Barnawi et al., 2020), histone methylation, and gene transcription (Saad et al., 2016) are independent of the actin-bundling activity of FSCN1. The gene discussed is FSCN1; the disease is cancer.