In addition to studies on FSCN1 promoting the migration and invasion of tumor cells via its action-bundling activity (Liu et al., 2021), the formation of filopodia and invadopodia (Li et al., 2010; Machesky and Li, 2010), focal adhesion dynamics (Villari et al., 2015), and extracellular vesicle release (Clancy et al., 2019), numerous studies have also reported various upstream factors regulating FSCN1 in EC progression. This evidence concerns the gene FSCN1 and neoplasm.