For example, microRNA (miR)-145, miR-133a, miR-328, and miR326 target FSCN1 to suppress ESCC, and long non-coding RNA (lncRNA) LOC146880, lncRNA PVT1, lncRNA01711, and lncRNA00337 confer EC progression by inhibiting the miR/FSCN1 pathway (Kano et al., 2010; Akanuma et al., 2014; Shen et al., 2019; Shi et al., 2020; Tang et al., 2021; Xu et al., 2021). The gene discussed is FSCN1; the disease is esophageal squamous cell carcinoma.