It was shown that oridonin (1) significantly reduced the inward flow of iodine ions in wt-CFTR and F508-CFTR FRT epithelial cells in a dose-dependent manner, and also reduced cholera toxin-induced humoral secretion, making it a candidate compound for the treatment of cholera toxin-induced secretory diarrhea (Luan et al., 2015). The gene discussed is CFTR; the disease is Secretory diarrhea.