In our study, with the treatment of PAP, the expressions of Ac-NF-κB, NF-κB, NLRP3, ASC, Ac-Caspase-1, Caspase-1, GSDMD-N, Cleaved-IL-1β, and Cleaved-IL-18 in the hippocampus were significantly downregulated compared with those of the CUMS group, indicating that PAP may have an effect on the whole process of depression-induced pyroptosis. Here, NLRP3 is linked to major depressive disorder.