The therapeutic effect of PAP on depression-like behaviors and its regulatory role on protein expressions of NF-κB, NLRP3, ASC, Caspase-1, GSDMD-N, Cleaved-IL-1β, and Cleaved-IL-18, etc., paved the way for us to understand PAP and its effect on pyroptosis. Here, CASP1 is linked to major depressive disorder.