NR1I2 and acute kidney injury: The finding is consistent with previous findings, Luan et al. suggested that PXR activation may protect TECs from apoptosis in AKI by regulating the PI3K/AKT signaling (Luan et al., 2021); Yu et al. determined that PXR targeted AKR1B7 to improve mitochondrial metabolism and restored renal function in AKI (Yu et al., 2020).