The nuclear receptor family has shown a percentage of 19.3% association on Salvia miltiorrhiza treatment in AKI with 11 target genes involved (AKR1B1, AR, CYP1A1, ESR1, ESR2, NR1I2, NR3C1, PGR, PPARG, RXRA, and STAT3). The gene discussed is ESR1; the disease is acute kidney injury.