CXCR1 and leukodystrophy: As for the difference between advanced (HLD) and early (non-HLD) pathology stages, the comparison reveals an increase in the expression of antigen-presenting receptors, complement binding regions, and chemokine receptors, thus the activity in the intracellular membranes (BP, MF, and CC aspects) in the HLD group, which collectively produce enhanced cell adhesion pathways.