Only three hub genes were identified for non-HLD vs. Ctrl comparison, AQP9, S100A8, and FPR1. AQP9 was previously reported in the top 25 hub gene list in the Gamper and colleagues (2009) in their gene expression profile study conducted with ulcerative IC (Gamper et al., 2009). The gene discussed is S100A8; the disease is leukodystrophy.