Diarrhea; vomiting; nausea; abdominal discomfort; thirst; sinus bradycardia; hypertension; orthostatic hypotension; hypertriglyceridemia; decreased appetite; fatigue; dyspnoea; flush; kidney injury; coagulation dysfunction; blurred vision; decreased WBC; increased alanine aminotransferase; increased serum amylase; decreased neutrophil count; disease progression*; upper respiratory tract*. The gene discussed is GPT; the disease is Bradycardia.