cTnI and CK-MB are powerful biomarkers for sensitive and specific detection of cardiomyopathies such as DCM or cardiac injury from various causes while BNP is a non-specific but sensitive biomarker for predicting cardiac dysfunction including DCM (Atabek et al., 2004; Korraa et al., 2012; El-Saiedi et al., 2020; Ajiboye et al., 2021). The gene discussed is NPPB; the disease is familial dilated cardiomyopathy.