MAS1 and cardiovascular disorder: It has been reported (Yang et al., 2017) that HD can stimulate the ACE/Ang II/AT1R axis (Angiotensin Converting Enzyme/Angiotensin II/Angiotensin Receptor 1) in the circulation of patients with cardiovascular disease, thereby reducing the activity of the ACE2/Ang- (Ureña, 2008; Hsiao et al., 2015; Naicker et al., 2020; National Health Commissio, 2020; Xiong et al., 2020; Zou et al., 2020; Bai et al., 2021)/Mas axis and reducing the concentration of ACE2.