DUSP1 and malignant colon neoplasm: Previous studies showed that the DUSP1 gene, as a transcriptional target of the p53 tumor suppressor, is highly expressed in prostate cancer (Hou et al., 2012) and played a vital role to inhibit tumor progression in these tumors such as prostate cancer, bladder cancer, and colon cancer (Slattery et al., 2012).