FASN and familial pancreatic carcinoma: FASN is a critical enzyme of synthetizing long-chain FAs from malonyl-CoA and acetyl-coenzyme A (CoA) and has been identified at high levels in several human cancers such as prostate cancer (Souchek et al., 2017), pancreatic cancer (Alo et al., 2007), breast cancer (Gonzalez-Guerrico et al., 2016), and colorectal cancer (Zaytseva et al., 2015).