Recently, some studies showed that as a proto-oncogene, MARCKS takes part in the tumorigenesis and development of several cancers such as lung cancer (Rohrbach et al., 2015), breast cancer (Chen et al., 2015), renal cell carcinoma (Chen et al., 2017), pancreatic cancer (Brandi et al., 2016), and HCC (Naboulsi et al., 2016) and plays an important role in participation in signaling pathways of many cancers. This evidence concerns the gene MARCKS and hereditary clear cell renal cell carcinoma.