HMOX1 and chronic obstructive pulmonary disease: Recently, studies have found that resveratrol could protect against oxidative damage and pulmonary inflammation on the COPD mice model (Liu et al., 2014a; Wang et al., 2017), where the mechanism might be related with decreasing NF-κB activity and elevated HO-1 expression, and activating the SIRT1/PGC-1α signaling pathways (Wang et al., 2017).