Beyond these molecules mentioned previously, as a variant of flavonoid, isoliquiriti-genin (ILG) derived from the root of liquorice was reported to antagonize COPD on CS-induced mice model by suppressing inflammatory and oxidative stress through up-regulating the expression of Nrf2 and down-regulating the expression of NF-κB signaling pathways (Yu D. et al., 2018). The gene discussed is NFKB1; the disease is chronic obstructive pulmonary disease.