Except for icariin suppressing NF-κB activation, casticin, which was a poly-methylflavone obtained from Vitex species such as Vitex rotundifolia and Vitex agnus-castus, was found possessing significant effects on attenuating oxidative stress and lung inflammation induced by CS (Lee et al., 2015), which was related to the inhibition of NF-ĸB pathway (Li et al., 2020). The gene discussed is NFKB1; the disease is Cowden syndrome 1.