The polyphenol compound curcumin enables the promotion of airway inflammation and airway remodeling in COPD model animals by regulating the NF-κB signaling pathway (Yuan et al., 2018), and improves skeletal muscle dysfunction by up-regulating the PGC-1α/SIRT3 pathway (Zhang et al., 2017). Here, NFKB1 is linked to chronic obstructive pulmonary disease.