Furthermore, houttuynia, one of the main components of the cordate houttuynia, could alleviate lung injury in the rats’ lung tissues of COPD induced by smoking combined with intratracheal instillation of LPS via inhibiting the TLR4/MyD88/NF-κB activation sequence (Wang et al., 2021). This evidence concerns the gene NFKB1 and chronic obstructive pulmonary disease.