Thus, Lixing Gan et al. investigated the functions variation of histone modification via a combination with the expression of chemokines in type-II alveolar epithelial cells (AEC II) and HDAC2 caused by curcumin on a mice model with COPD induced by CS, and the results indicated that curcumin might inhibit chemokines and rebuild corticosteroid resistance in COPD through modulating HDAC2 expression, as well as show influence on histone modification (Gan et al., 2016). The gene discussed is HDAC2; the disease is chronic obstructive pulmonary disease.