Increasing evidence has shown that hypermethylation in the 5′–C–phosphate–G–3 (5′-CpG-3′) islands of the promoter region of miRs, functioning as tumor suppressors by DNMT-1, often mediates activation of the proliferation or drug-resistance-related pathways (Wong, 2020; Wong, 2021; You et al., 2021). Here, DNMT1 is linked to neoplasm.