Several in vitro and in vivo studies have validated the potent part played by STAT3 in precancerous physiology of the stomach, implying that STAT3 could be used as a predictive marker for diagnosis of GC, thus inhibiting STAT3 activity with several inhibitory molecules might help to prevent cancer (Khanna et al., 2015) (Table 2). This evidence concerns the gene STAT3 and gastric cancer.