Moreover, it was also demonstrated by Real et al that the overexpression of Bcl-2 mediated by STAT3 inhibited chemotherapy-induced apoptosis in BC cells (Liao et al., 2017), while another study by Masuda et al demonstrated that STAT3 inhibition improved the sensitivity of head and neck cancer cells to 5-Fluorouracil. The gene discussed is STAT3; the disease is head and neck cancer.