Apart from the genetic predisposition of BRCA1/2, PTEN and TP53 mutations in high-risk groups, the other genetic expression profile of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor-2 (HER-2) contributes to the pathogenesis and stratification of BC (Chen et al., 2020). This evidence concerns the gene ESR1 and breast cancer.