KDR and gastric cancer: These genomic mutations lead to aberrant activation of several signaling molecules, such as vascular endothelial growth factor receptor (VEGFR) family, epidermal growth factor receptor family (ErbB) members, and various components of JAK/STAT and PI3K/Akt/mTOR pathway thereby contributes in the molecular pathogenesis of GC (Khanna et al., 2015; Yeh et al., 2016; Zhu et al., 2019).