The tumor microenvironment appears to get affected by the constitutive activation of STAT3 through the secretion of several cytokines, e.g., Interleukin-10, Interleukin-6, Interleukin1β, by cancer cells which activate noncancerous cells, tumor associated macrophages and T-helper (Th)-17 cells to release more cytokines, thereby contributing a positive feedback circle (Jeannin et al., 2018; Duan et al., 2020). This evidence concerns the gene STAT3 and cancer.