Monoclonal antibodies (such as HER2, VEGFR, or EGFR), multikinase inhibitors, and immune checkpoint inhibitor therapy (such as CTLA-4 or PD-1/PD-L1 are mainly involved in targeted therapy that has shown to be beneficial in the treating metastatic and advanced stages of GC patients (Seebacher et al., 2019). Here, EGFR is linked to gastric cancer.