IL6 and neoplasm: The activity of JAK and STAT3 is enhanced due to the overexpression of pro-inflammatory cytokines like IL-6, IL-10, IL-11, and TGF-α to regulate the tumor micro-environment, which eventually create the oncogenic conditions to inhibit apoptosis (Waters and Brooks, 2015; Ferrao et al., 2016; Yuan et al., 2017; Wu et al., 2018).