Given that PBI-05204 is capable of down regulating PI3Kinse and mTOR pathways in both pancreatic cancer and GBM (Pan et al., 2015), whether PBI-05204 elicited reduction of DNA repair caused by RT is mediated through reduction of PI3K/mTOR pathway by PBI-05204 is deserving of further investigation. This evidence concerns the gene MTOR and glioblastoma.