To conclude, this study used an intrathecal delivery technique to demonstrate that continuous intrathecal OT infusion attenuated the subsequent establishment and development of nerve injury-induced neuropathic pain and renormalized neuronal chloride homeostasis via upregulation of KCC2 expression and function, which may be caused by OT-induced activation of GABA inhibitory transmission. The gene discussed is SLC12A5; the disease is injury.