YTHDF2 and rheumatoid arthritis: Luo et al. (2020a) confirmed that, in RA, decreased alkB homolog 5 (ALKBH5), fat mass and obesity-associated protein (FTO), and YTH domain-containing family member 2 (YTHDF2) expression in peripheral blood mononuclear cells (PBMCs) is a risk factor for RA, and other research has shown that methyltransferase like 3 (METTL3) expression is greatly increased in the PBMCs of RA patients (Wang et al., 2019). Nevertheless, the transcriptome-wide m6A methylome in RA has not been fully characterized, and more in-depth research is rare.