IL17A and rheumatoid arthritis: These dysregulated genes were significantly involved in “signal transduction,” “cell adhesion” and “neutrophil degranulation.” In KEGG pathway analyses, several canonical pathways associated with RA inflammation were significantly enriched, including “complement and coagulation cascades,” “Jak-STAT signaling pathway” and “IL-17 signaling pathway.” However, the downregulated genes were significantly related to “natural killer cell mediated cytotoxicity.”