NFE2L2 and liver dysplastic nodule: The activation of Nrf2 has been shown to inhibit the excessive accumulation of intracellular reactive oxygen species (ROS) by regulating the expression of endogenous antioxidant enzymes, which in turn inhibits the development of oxidative stress-induced fibrotic injury in DN (Li et al., 2012; Bhakkiyalakshmi et al., 2015; Matzinger et al., 2018).