REN and acute respiratory distress syndrome: We also sorted the inflammatory signaling pathways in COVID-19-related ARDS, including those of IL-6/JAK/STAT, interferon, NF-κB, TLRs, Bruton’s tyrosine kinase, and renin–angiotensin system (Zhang and Guo, 2020; Choudhary et al., 2021), and 49 target genes were included for further analysis (Figure 1C).