In this study, age, sex, apoe4, income before tax, smoking status, alcohol status, BMI, hypertension, and diabetes had no interaction with LRUAC but qualification (college or university degree; NVQ or HND or HNC or equivalent) had a quantitative interaction with LRUAC on cognitive impairment: the effect of LRUAC on cognitive impairment diminished in participants with high qualification, which is consistent with a previous study (Ko et al., 2021). This evidence concerns the gene APOE and Cognitive impairment.