Neuroimaging evidence suggests that functional connectivity (FC) in this circuit is negatively correlated with depression severity (Du et al., 2017; Pantazatos et al., 2020), and increased FC between the PFC and cingulate gyrus is associated with depression-related gene orthodenticle homeobox 2 (OTX2) (Gärtner et al., 2019). The gene discussed is OTX2; the disease is major depressive disorder.