During the last decade, studies using positron emission tomography (PET) observed that dopamine transporter availability and noradrenergic innervation in the striatum and limbic brain regions were reduced in PD patients with depression compared to PD patients without depression (Burn et al., 2012; Vriend et al., 2014); and the alterations in dopamine transporter availability and noradrenergic innervation influence neural activity in cortical regions (Pa et al., 2013; Meyer et al., 2019). The gene discussed is SLC6A3; the disease is major depressive disorder.