NLRP3 and Parkinson disease: In the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD, neurotoxin MPTP activates NLRP3 inflammasome signaling to promote microglial recruitment, caspase-1 activation and interleukin-1β production in the substantia nigra of suffered brain, which is critical for dopaminergic neuronal loss and the subsequent motor deficits (Lee E. et al., 2019).