SNCA and Parkinson disease: Several independent studies have detected α-synuclein accumulation in transgenic GBA mouse models (Migdalska-Richards et al., 2017b), inhibited GCase activity in conduritol-β-epoxide-treated SH-SY5Y cell cultures and mice (Manning-Bog et al., 2009; Cleeter et al., 2013), and induced pluripotent stem cell (iPSC)-derived neurons obtained from GBA-associated PD patients and GD patients (Schondorf et al., 2014; Woodard et al., 2014; Fernandes et al., 2016).