Using ubiquitous overexpression of FLAG-Ube3a in a BAC transgenic mouse model for autism (Smith et al., 2011; Krishnan et al., 2017), we found that the circadian period of the SCN in vitro was shortened by the enhanced expression of Ube3a compared with that in WT SCN from the same mixed background (Figure 6A). Here, UBE3A is linked to autism.