A known cause of PMS is the dysfunction of SHANK3 (Phelan, 2008; Costales and Kolevzon, 2015; Tachibana et al., 2017; Mitz et al., 2018) and patients with PMS commonly display typical autism features, with some studies showing that these patients may also have skeletal muscle hypotonia, intellectual disability, developmental delay, and visual problems (Phelan et al., 2001, 2005; Phelan, 2008; Phelan and McDermid, 2012). The gene discussed is SHANK3; the disease is premenstrual tension.