The model of Shank3-mutant mice has exhibited molecular impairments in the cortex and hippocampus neurons, causing deficits in the NMDA receptor-mediated neurotransmission associated with cognitive deficits (Kouser et al., 2013; Duffney et al., 2015; Sala et al., 2015; Qin et al., 2018). This evidence concerns the gene SHANK3 and Cognitive impairment.