SHANK3 and premenstrual tension: It is well-known that patients with PMS have visual problems and Tatavarty’s work (Tatavarty et al., 2020) also shows that SHANK3 is essential for homeostatic plasticity in the mouse visual cortex, suggesting that there is a critical effect of SHANK3 in the visual signaling pathways (Phelan et al., 2005; Phelan, 2008; Phelan and McDermid, 2012).