Our finding is consistent with previous studies indicated that a decrease of GPX1 activity was found in mouse cochlea HCs and stria vascular after noise induced hearing loss (McFadden et al., 2001; Kil et al., 2007), and suggested that the antioxidant enzyme GPX1 might play a role in the oxidative injury of SGNs induced by peroxynitrite. This evidence concerns the gene GPX1 and hearing loss disorder.