GPX1 and noise induced hearing loss: Kil et al. (2007) have declared that GPX1 is the dominant isoform of GPXs family and is highly expressed in HCs, supporting cells, SGNs, stria vascularis, and spiral ligament in the rat cochlea. Additionally, the mice by knockout of GPX1 are more susceptible to NIHL compared with wild type mice (Ohlemiller et al., 2000; McFadden et al., 2001).