Moreover, ebselen increased the expression of GPX2 and GPX4 in SGNs after peroxynitrite injury (Supplementary Figure 3), which is consistent with previous studies that ebselen can increase the expression of GPX2 or GPX4 in rat stomach (Kumar et al., 2010), gastric cancer cells (Xu et al., 2018), or cochlea (Liang et al., 2019). Here, GPX4 is linked to gastric cancer.