FTO and Alzheimer disease: Reitz et al. (2012) used 1,877 Caucasian cases and controls from the NIA-LOAD study and 1,093 Caribbean Hispanics to further explore the association of FTO with AD. They found that genetic variation in Introns 1 and 2 of the FTO gene may contribute to AD risk (Reitz et al., 2012). The aforementioned studies suggested that maintaining a low and basic expression level of FTO in AD might be necessary for precise RNA m6A modification.