ABCA1 and Alzheimer disease: Jaouen and Gascon (2016) described miR-33 function modulating ATP-binding cassette transporter A1 (ABCA1) and interfering with Aβ plaque formation through cholesterol metabolism regulation. Peña-Bautista et al. (2021) found hsa-miR-421 showed a positive correlation with some detected lipids (FA (16:0), FA (20:2), FA (18:2), FA (20:4), FA (20:3), FA (18:0), FA (14:0)) in AD plasma samples. Docosahexaenoic acids (DHA) are known to be beneficial in AD. miR-33a and miR-145 are regulated by DHA, and this regulation becomes disrupted in AD (Chiang, 2021).