It has been known for several decades that AVP plays a critical role in promoting the formation of complex mammalian social behavior such as social cognition, social recognition, social exploration, and preference by acting on AVP receptors which mainly located in hippocampus, amygdala, striatum, and other “social brains.” In recent years, a growing number of scientific reports have shown that AVP is a crucial factor in neurodevelopmental disorders, including the ASD. This evidence concerns the gene AVP and neurodevelopmental disorder.