UBQLN1 and amyotrophic lateral sclerosis: A recent study showed that overexpression of UBQLN1 reduces neuropathology in a mouse model of amyotrophic lateral sclerosis with frontotemporal dementia (ALS/FTD) that contains a mutation in UBQLN2, a gene that encode an ubiquilin-1 homolog protein (Wang et al., 2020).