For example, to understand the role of the lysosomal degradation pathway in the pathogenesis of SCA7, a study focused on autophagy in SCA7 knock-in mouse models was performed, and the results were compared to observations made of postmortem brains and peripheral blood mononuclear cells (PBMC) from SCA7 patients. This evidence concerns the gene ATXN7 and spinocerebellar ataxia 7.